太田成男のちょっと一言関連発表論文 | 太田成男のちょっと一言

米国でも水素の効果を大きく報道しています。

水素関連論文

(1)　Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007; 13(6): 688-94. 日本医大加齢科学

水素分子（H2）が抗酸化剤として疾患の予防と治療に応用できることを科学的に証明した最初の論文。水素分子は活性酸素種の中で最も反応性の高いヒドロキシラジカルを選択的に還元し、細胞を酸化ストレスから防御することを示し、さらにラットに水素ガスを吸引させることで脳の虚血再還流障害が抑制できることを示した。

(2)　Katherine CW, Gladwin MT. The hydrogen highway to reperfusion therapy. Nat Med. 2007; 13: 673-4. Review
(1)の論文の紹介論文。

(3)　Oliver J. Hydrogen acts as an effective therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Kidney Int. 2007; 72: 393-4. Review
(1)の論文の紹介論文。

(4)　Fukuda K, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun. 2007; 361(3): 670-4. 日本医大加齢科学
水素ガスの吸引によって酸化ストレスが軽減し、肝臓の虚血再灌流障害を軽減したことを示した。

(5)　Ball J. Recently published papers: more about EGDT, experimental therapies and some inconvenient truths. Crit Care. 2007;11(5):171. Review
(1)の論文の紹介論文。

(6)　Singhal AB, Lo EH. Advances in emerging nondrug therapies for acute stroke 2007. Stroke. 2008; 39(2):289-91. Review
(1)の論文の紹介論文。

(7)　Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, Makino S, Ohta S, Ogawa S, Fukuda K. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun. 2008,373(1):30-5．慶應義塾大学再生医学と日本医大加齢科学
水素ガスの吸入によって、心筋梗塞、虚血再灌流障害を軽減したことを示した。

(8)　Buchholz BM, Kaczorowski DJ, Sugimoto R, Yang R, Wang Y, Billiar TR, McCurry KR, Bauer AJ, Nakao A. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant. 2008; 8(10):2015-24．ピッツバーグ大学
小腸移植についてのラットを用いたモデル実験で供与側と受容側の両方のラットに水素ガスを吸引させたところ、術後の障害が有意に軽減された。この時、酸化ストレスの減少に伴う炎症性サイトカインの抑制を認めた。

(9)　Cai J, Kang Z, Liu WW, Luo X, Qiang S, Zhang JH, Ohta S, Sun X, Xu W, Tao H, Li R. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci lett. 2008,441(2):167-72．上海第二軍事医科大
ラット新生仔の低酸素による脳細胞死を水素ガスの吸引が抑制できることを示した．

(10)　Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, Kitawaki J, Imai S, Nakano K, Ohta M, Adachi T, Obayashi H, Yoshikawa T. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance, Nutr Res. 2008; 28(3):137-43．京都府立医大
水素水を２型糖尿病患者に与え、その効果を調べた．脂質と糖代謝が改善され、耐糖能障害が抑制されることを示した．臨床試験で水素分子の効果を報告した最初の論文。

(11)　Renault JP, Vuilleumier R, Pommeret S. Hydrated Electron Production by Reaction of Hydrogen Atoms with Hydroxide Ions: A First-Principles Molecular Dynamics Study. J Phys Chem. 2008; A, 112: 7027–34. CNRS, France
水素とヒドロキシルラジカル反応の物理学的検討。

(12)　Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S. Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology. 2009; 34(2):501-8. 日本医大加齢科学
水素水を飲用することで、疾患防御に効果があることを実験的に示した最初の論文．拘束することで長期間身体的ストレスを与えたマウスは、学習・記憶能力が低下する．このマウスに水素水を与えるとその低下を予防することができた．拘束により脳における酸化ストレスの蓄積と歯状回神経前駆細胞の増殖低下が観察されるが、そのいずれも水素水によって抑制された。

(13)　Sato Y, Kajiyama S, Amano A, Kondo Y, Sasaki T, Handa S, Takahashi R, Fukui M, Hasegawa G, Nakamura N, Fujinawa H, Mori T, Ohta M, Obayashi H, Maruyama N, Ishigami A.: Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun. 2008; 375(3): 346-50. 東邦大薬学部
ビタミンC欠損マウスに水素水を飲ませると、そのネズミから調製した脳スライスにおいて、虚血再還流によるスーパーオキサイド産生が抑制された。

(14)　Press release from Toho Univ.　東邦大学

(15)　Nakao A, Sugimoto R, Billiar TR, McCurry KR.Therapeutic antioxidant medical gas. J Clin Biochem Nutr. 2009; 44(1):1-13. Review　ピッツバーグ大
水素分子を含むメディカルガスについての総説

(16)　Ohsawa I, Nishimaki K, Yamagata K, Ishikawa M, Ohta S. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys Res Commun. 2008; 377(4):1195-8　日本医大加齢科学
動脈硬化が生じやすいマウスに水素水を４ヶ月間飲ませると動脈硬化が抑制された。同じ条件で比べると他の抗酸化物質よりも水素水が効果的であった。

(17)　総説　水素ガスと水素水による新しい概念の抗酸化治療と予防医学、太田成男、日本老年医学会雑誌45(4)：355-62（2008）日本医大加齢科学

(18) 　総説　水素分子による新しい概念の抗酸化治療法と予防医学、実験医学、26（13）2074-80（2008）太田成男、日本医大加齢科学

(19)　総説　誌上デベート：水素水は体によいか？悪いか？アンチ・エイジング医学−日本抗加齢医学会雑誌　4(6)777-84　(2008) 太田成男、日本医大加齢科学

(20)　総説　水素ガスと水素水による新しい概念の抗酸化治療と予防医学、太田成男、老年医学update2009-2010：pp89-99　日本老年医学会雑誌編集委員会　(2009) 日本医大加齢科学

(21)　Fu Y, Ito M, Fujita Y, Ito M, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, Ohsawa I, Ohta S, Ohno K. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. Neurosci Lett. 2009; 453(2): 81-5. 名古屋大神経科学
ラットに6-hydroxydopamineを注入し脳の黒質領域を変性させパーキンソン病のモデル動物を作製した。５０％飽和水素水を与えてからモデル動物を作製すると黒質の変性の進行が抑制され，パーキンソン病に似た挙動が抑制された。また、パーキンソン病モデルを作製した後に水素水を飲ませても病状が改善された。

(22)　市原正智、祖父江紗矢加、竹内環　分子状水素の臨床応用に向けた研究の現状について　　総説　中部大

(23)　Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S. Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol. 2009; 64(4): 753-61. 日本医大加齢科学
水素ガスの吸入と水素水の飲用が抗がん剤のひとつのシスプラチンの副作用を軽減することをマウスを用いて明らかにした。シスプラチンにより腎臓に与えられた酸化ストレスを水素が軽減した。また、他の抗酸化物質よりも水素水の効果は大であった。

(24)　Cai J, Kang Z, Liu K, Liu W, Li R, Zhang JH, Luo X, Sun X. Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res, 2009; 1256: 129-37. 上海第二軍事医科大
水素を生理的食塩水に溶かして静脈注射するとラットの新生児の虚血再灌流による酸化ストレス障害を軽減することがわかった。水素を含む生理的食塩水の静脈注射の効果を報告した最初の論文。

(25)　Zheng XF, Mao YF, Cai JM, Li YH, Liu WW, Sun PL, Zhang JH, Sun XJ, Yuan.HB Hydrogen-Rich Saline Protect s against Intestinal Ischemia/Reperfusion Injury in Rats. Free Radical Res. 2009; 43(5):478-84. 上海第二軍事医科大
水素分子を溶かした生理的食塩水の注入は、虚血再灌流による小腸障害を抑制した。

(26)　Matchett GA, Fathali N, Hasegawa Y, Jadhav V, Ostrowski RP, Martin RD, Dorotta IR, Sun X, Zhang JH. Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models. Brain Res. 2009; 1259:90-7. ローマリンダ大、カリファルニア
新生児の虚血再灌流障害が強度の時は水素ガスが効果的でないことを示した。

(27)　Mao YF, Zheng XF, Cai JM, You XM, Deng XM, Zhang JH, Jiang L, Sun XJ. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun. 2009; 381(4):602-5. 上海第二軍事医科大
水素を含む生理的食塩水の静脈注射が、小腸の虚血再灌流によって生じた肺の障害を軽減したことを示した。

(28)　Shimouchi A, Nose K, Yamaguchi M, Ishiguro H, Kondo T.: Breath Hydrogen Produced by Ingestion of Commercial Hydrogen Water and Milk. Biomarker Insights. 2009;4: 27-32. 国立循環器センター
ミルクを飲む事によって呼気の水素ガス量が増加することを示し、腸内細菌による水素ガスを上昇させることを示唆した。

(29)　Kikkawa YS, Nakagawa T, Horie RT, Ito J. Hydrogen protects auditory hair cells from free radicals. Neuroreport. 2009;20(7):689-94. 京都大耳鼻科
水素分子によって内耳細胞をフリーラジカルから防御することを示した。

(30)　Suzuki Y, Sano M, Hayashida K, Ohsawa I, Ohta S, Fukuda K. Are the effects of α-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? FEBS Lett. 2009 ; 583(13):2157-9. 日本医大加齢科学、慶應義塾大再生医学
糖尿病の薬剤によって腸内細菌を増加させて体内の水素分子量を増加させ、酸化ストレスを軽減させ、心筋血管障害や高血圧症が軽減させることを示唆した。

(31)　Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M; STOP-NIDDM Trial Research Group.: Acarbose treatment and the risk of cardiovascular diseases and hypertension in patients with impaired glucose tolerance JAMA. 2003290(4): 486-94.
(30)の関連論文。糖尿病治療薬が心臓・血管病の発症と高血圧を予防することを示した。腸内細菌の水素ガスによる効果であることで説明できる。

(32)　Satoh N, Shimatsu A, Yamada K, Aizawa-Abe M, Suganami T, Kuzuya H, Ogawa Y.: An α-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients. Metabolism Clinical and Experimental. 200655(6): 786-93.
(30)の関連論文。糖尿病治療薬が心臓・血管病の発症と高血圧を予防することを示した。腸内細菌の水素ガスによる効果であることで説明できる。

(33)　Kajiya M, Sato K, Silva MJ, Ouhara K, Do PM, Shanmugam KT, Kawai T. Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun. 2009; 386(2):316-21.　フォーシス研究所、ボストン
遺伝子組み換えによって水素を発生しない大腸菌を作り出し、腸内に戻す事により、腸内細菌が発生する水素に抗炎症作用があることを示した論文。コンカナバリンAによって、肝炎を生じさせた。

(34)　Kajiya M, Silva MJ, Sato K, Ouhara K, Kawai T. Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun. 2009;36(1):11-5. フォーシス研究所、ボストン
遺伝子組み換えによって水素を発生しない大腸菌を作り出し、腸内に戻す事により、腸内細菌が発生する水素に抗炎症作用があることを示した論文。デキストランナトリウム硫酸を用いて、大腸への炎症を生じさせた。

(35)　Sun Q, Kang ZM, Cai JM, Liu WW, Liu Y. Zhang JH, Denoblec PJ, Tao HY, Sun XJ. Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats. Exp Biol Med. 2009; 234 (10): 1212-9. 上海第二軍事医科大
水素を溶解した生理的食塩水の投与により虚血再灌流の心筋の障害を軽減することを示した論文。

(36)　Chen H, Sun YP, Hu PF, Liu WW, Xiang HG, Li Y, Yan RL, Su N, Ruan CP, Sun XJ, Wang Q. The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. J Surg Res. 2009Aug 27.in press. 2011;167(2)316-22.　上海第二軍事医科大
水素分子を溶解した生理的食塩水の注入により虚血再灌流による小腸の収縮性と構造的変化を改善した。

(37)　Milton SL. HYDROGEN SALINE A REAL GAS. J Exp Biol. 2009 in press (comment to the above paper)
(36)の論文の紹介記事。

(38)　Liu C, Cui JG, Sun Q, Cai JM. Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome. Med Hypotheses. 2010;74:145-6.上海第二軍事医科大
急性放射線障害に水素ガスが効果的であることを示唆し、今後の治療法の可能性を示した。

(39)　Shimouchi A, Nose K, Takaoka M, Hayashi H, Kondo T. Effect of dietary turmeric on breath hydrogen. Dig Dis Sci. 2009; 54(8):1725-9. 国立循環器センター
ウコンが腸内細菌から発生する水素分子量を増加させることを示した。

(40)　Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, Noda M. Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. PLoS One. 2009;4(9):e7247.（九州大薬学部）
MPTP投与によるパーキンソン病モデルマウスに対し、水素水の飲用効果を示した。水素水の5%飽和溶液の飲用でもパーキンソン病モデルの予防効果があることを示した。

(41)　藤田慶大。パーキンソン病モデルマウスにおける水素含有飲用水の効用（九州大薬学部）総説
第19回病態生理学会奨励賞受賞講演

(42)　Oharazawa H, Igarashi T, Yokota T, Fujii H, Suzuki H, Machide M, Takahashi H, Ohta S, Ohsawa I. Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 2010;51(1):487-92.日本医科大眼科
水素分子を含む生理的食塩水の点眼によって、眼の酸化ストレスが軽減することを示した。水素分子が眼球の中まで到達する事を示した。

(43)　Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry KR, Billiar TR, Nakao A. Oral administration of hydrogen water prevents chronic allograft nephropathy in rat renal transplantation. Kidney Int. 2010; 77(2):101-9. ピッツバーグ大
腎臓移植における水素水の飲用効果を示し、その分子機構を解明した。この論文の図が表紙になり、Hydrogen Waterとして紹介された。

(44)　George JF, Agrwal. Hydrogen: another gas with therapeutic potential. Kidney Int. 2010; 77; 85-7. review
(43)の紹介記事。

(45)　Nakao A, Kaczorowski DJ, Wang Y, Cardinal JS, Buchholz BM, Sugimoto R, Tobita K, Lee S, Toyoda Y, Billiar TR, McCurry KR. Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. J Heart Lung Transplant. 2010;29(5):544-53. ピッツバーグ大
水素ガスの一酸化炭素の吸引によって、心筋の虚血再灌流障害に対し相乗効果を示した。

(46)　Itoh T, Fujita Y, Ito M, Masuda A, Ohno K, Ichihara M, Kojima T, Nozawa Y, Ito M. Molecular hydrogen suppresses FceRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun. 2009;389(4):651-6. 岐阜国際バイオ研究所
水素分子に抗アレルギー作用があることを示した最初の論文。さらに、水素分子が生体内シグナルとして機能する事を示唆した。

（上へ）

(47)　Xie K, Yu Y, Pei Y, Hou L, Chen S, Xiong L, Wang G. Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Shock. 2010;34(1):90-7.
水素ガスの吸引によって、酸化ストレスが軽減し、HMGB1の遊離を軽減させ、敗血症による多臓器障害を軽減させた。

(48)　Nakao A, Toyoda Y, Sharma P, Evans M, Guthre N. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndtrome— An open label pilot study. J Clin Biochem Nutr. 2010; 46(2): 140-9.　ピッツバーグ大学
メタボリック症候群の予備軍に水素水を飲ませ、酸化状態を軽減させた。盲検試験ではない臨床試験。

(49)　Saitoh Y, Okayasu H, Xiao L, Harata,Y, Miwa N.: Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression. Oncol Res. 2008:17 (6): 247-55.

(50)　Saitoh Y, Yoshimura Y, Nakano K, Miwa N.: Platinum nanocolloid-supplemented hydrogendissolved water inhibits growth of human tongue carcinoma cells preferentially over normal cells. Experimental Oncol. 2009;31(3):156–62.

(51)　Qian L, Cao F, Cui J, Huang Y, Zhou X, Liu S, Cai J.: Radioprotective effect of hydrogen in cultured cells and mice. Free Radical Res. 2010; 44(3):275-82.

(52)　Hiraoka A, Inaba H, Suzuki E, Kasai K, Suzuki H, Shinohara A, Shirao M, Kubo K, Yoshimura Y.: In vitro physicochemical properties of neutral aqueous solution systems (water products as drinks) containing hydrogen gas, 2-carboxyethyl germanium sesquioxide, and platinum nanocolloid as additives. J Health Sci. 2010; 56(2):167-74.

(53)　Saitoh Y, Harata Y, Mizuhashi F, Nakajima M, Miwa N.: Biological safety of neutral-pH hydrogen-enriched electrolyzed water upon mutagenicity, genotoxicity and subchronic oral toxicity. Toxicol Ind Health. 2010;26(4):203-16.

(54)　Zheng J, Liu K, Kang Z, Cai J, Liu W, Xu W, Li R, Tao H., Zhang J.H, Sun X.: Saturated hydrogen saline protects the lung against oxygen toxicity. Undersea Hyperb Med. 2010;37(3):185-92.

(55)　Chen H, Sun YP, Li Y, Liu WW, Xiang HG, Fan LY, Sun Q, Sun XJ, Wang Q.:Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats. Biochem Biophys Res Commun, 2010; 393(2):308-13.

(56)　Li J, Wang C, Zhang JH, Cai JM, Cao YP, Sun XJ.: Hydrogen-rich Saline Improves Memory Function in a Rat Model of Amyloid-beta-induced Alzheimer’s Disease by Reduction of Oxidative Stress. Brain res. 2010;1328:152-61.

(57)　Shen MH, Cai JM, Sun Q, He J, Sun XJ, Huo ZL.:Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning. Medical Hypotheses. 2010;75(2):235-7.

(58)　Chen C, Chen Q, Mao Y, Xu S, Xia C, Shi X, Zhang JH, Yuan H, Sun X.: Hydrogen-rich saline protects against spinal cord injury in rats. Neurochem Res. 2010; 35(7): 1111-8.

(59)　Liu Q, Shen WF, Sun HY, Fan DF, Nakao A, Cai JM, Yan G, Zhou WP, Shen RX, Yang JM, Sun XJ.: Hydrogen-Rich Saline Protects against Liver Injury in Rats with Obstructive Jaundice. Liver Int. 2010;30(7):958-68.

(60)　Xie K, Yu Y, Zhang Z, Liu W, Pei Y, Xiong L, Hou L, Wang G.: Hydrogen gas improves survival rate and organ damage in zymosan-induced generalized inflammation model. Shock. 2010;34(5):495-501.

(61)　Chen CH, Anatol M, Zhan Y, Liu WW, Ostrowki RP, Tang J, Zhang JH.: Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model. Neuroscience. 2010;169(1):402-14.

(62)　Nakayama M, Nakano H, Hamada H, Itami N, Nakazawa R, Ito S.: A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial. Nephrol Dial Transplant. 2010;25(9):3026-33.

(63)　Shingu C, Koga H, Hagiwara S, Matsumoto S, Goto K, Yokoi I, Noguchi T.: Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury. J Anesth. 2010;24(4):569-74.

(64)　Gu Y, Huang CS, Inoue T, Yamashita T, Ishida T, Kang KM, Nakao A.: Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice. J Clin Biochem Nutr. 2010; 46(3):269-76.

(65)　Kitamura A, Kobayashi S, Matsushita T, Fujinawa H, Murase K.: Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. Br J Radiol. 2010;83(990):509-14.

(66)　Kawasaki H, Guan J, Tamama K.: Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials. Biochem Biophys Res Commun. 2010;397(3):608-13.

(67)　Ji X, Liu W, Xie K, Liu W, Qu Y, Chao X, Chen T, Zhou J, Fei Z.: Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain res. 2010; 1354: 196-205.

(68)　Domoki F, Oláh O, Zimmermann A, Németh I, Tóth-Szűki V, Hugyecz M,: Temesvári P, Bari F.: Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs. Pediatric Research. 2010; 68(5):387-92.

(69)　Ueda Y, Nakajima A, Oikawa T.: Hydrogen-Related Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Coral Calcium Hydride. Neurochem Res. 2010;35(10):1510-5.

(70)　Liu S, Sun Q, Tao H, Sun X.: Oral administration of mannitol may be an effective treatment for ischemia-reperfusion injury. Med Hypotheses. 2010;75(6):620-2.

(71)　Qian L, Li B, Cao F, Huang Y, Liu S, Cai J. Gao F.: Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage. Nuclear Technol Radiation Protection. 2010;25(1):23-9.

(72)　Yan H, Tian H, Kinjo T, Hamasaki T, Tomimatsu K, Nakamichi N, Teruya K, Kabayama S, Shirahata S.: Extension of the lifespan of Caenorhabditis elegans by the use of electrolyzed reduced water. Biosci Biotechnol Biochem. 2010 ;74(10):2011-5.

(73)　Taura A, Kikkawa YS, Nakagawa T, Ito J.: Hydrogen protects vestibular hair cells from free radicals. Acta oto-laryngologica 2010; 130 (SUPPL. 563): 95-100.

(74)　Qian L, Cao F, Cui J, Wang Y, Huang Y, Chuai Y, Zaho L, Jiang H, Cai J.: The potential cardioprotective effects of hydrogen in irradiated mice. J Radiat Res (Tokyo). 2010;51(6):741-7.

(75)　Kawamura T, Huang CS, Tochigi N, Lee S, Shigemura N, Billiar TR, Okumura M, Nakao A, Toyoda Y.: Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. Transplantation. 2010; 90(12): 1344-51.

(76)　Huang CS, Kawamura, T , Toyoda, Y , Nakao, A.: Recent advances in hydrogen research as a therapeutic medical gas. Free Radical Res. 2010; 44(9):971-82.

(77)　Huang CS, Kawamura T, Lee S, Tochigi N, Shigemura N, Buchholz BM, Kloke JD, Billiar TR, Toyoda Y, Nakao A.: Hydrogen inhalation ameliorates ventilator-induced lung injury. Crit Care. 2010;14(6):R234.

(78)　Weng, YC, Hung, KC, Wang, JC, Lee, YG, Su, YF, Lin, CY: Binary platinum-ruthenium/Nafion electrodes for the detection of hydrogen. Sensors and Actuators B Chemical 2010; 150(1):264-70.

(79)　Kanazuru T, Sato EF, Nagata K, Matsui H, Watanabe K, Kasahara E, Jikumaru M, Inoue J, Inoue M.: Role of hydrogen generation by Klebsiella pneumoniae in the oral cavity. J Microbiol. 2010 ;48(6):778-83.

(80)　Hong Y, Chen S, Zhang JM.: Hydrogen as a selective antioxidant: a review of clinical and experimental studies. J Int Med Res. 2010;38(6):1893-903.

(81)　Lin Y, Kashio A, Sakamoto Y, Suzukawa K, Kakigi A, Yamasoba T,: Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs. Neurosci Lett. 2011;487 (2011):12-6.

(82)　Schoenfeld MP, Ansari RR, Zakrajsek JF, Billiar TR, Toyoda Y, Wink DA, Nakao A.: Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight. Med Hypotheses 2011;76 (2011):117–8.

(83)　Zhang Y, Sun Q, He B, Xiao J, Wang Z, Sun X.: Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. Int J Cardiol. 2011;148:91-5.

(84)　Sun Q, Cai J, Liu S, Liu Y, Xu W, Tao H, Sun X.: Hydrogen-Rich Saline Provides Protection Against Hyperoxic Lung Injury. J Surg Res. 2011;165(1):e43-9.

(85)　Wang C, Li J, Liu Q, Yang R, Zhang JH, Cao YP, Sun XJ.: Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer’s disease. Neurosci Lett. 2011;491(2):127-32.

(86)　Huang Y, Xie K, Li J, Xu N, Gong G, Wang G, Yu Y, Dong H, Xiong L.:Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits. Brain Res. 2011;1378:125-36.

(87)　Chen X, Zuo Q, Hai Y, Sun XJ.: Lactulose: an indirect antioxidant ameliorating inflammatory bowel disease by increasing hydrogen production. Med Hypotheses. 2011;76(3):325-7.

(88)　Zheng XF, Sun XJ, Xia ZF.: Hydrogen Resuscitation, a New Cytoprotective Approach. Clin Exp Pharmacol Physiol. 2011; 38 (3):155-63 .

(89)　Sun H, Chen L, Zhou W, Hu L, Li L, Tu Q, Chang Y, Liu Q, Sun X, Wu M, Wang H.: The protective role of hydrogen-rich saline in experimental liver injury in mice. J Hepatol. 2011;54(3):471-80.

(90)　Kamimura N, Nishimaki K, Ohsawa I, Ohta S.: Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice. Obesity (Silver Spring). 2011 19(7):1396-403.

(91)　Kubota M, Shimmura S, Kubota S, Miyashita H, Kato N, Noda K, Ozawa Y, Usui T, Ishida S, Umezawa K, Kurihara T, Tsubota K.: Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Invest Ophthalmol Vis Sci. 2011;52(1):427-33.

(92)　Sun Q, Cai J, Zhou J, Tao H, Zhang JH, Zhang W, Sun XJ.: Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity*. Crit Care Med. 2011; 39 (4):765-9.

(93)　Li Y, Hamasaki T, Nakamichi N, Kashiwagi T, Komatsu T, Ye J, Teruya K, Abe M, Yan H, Kinjo T, Kabayama S, Kawamura M, Shirahata S.: Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology. 2011;63(2):119-31.

(94)　Liu S, Liu K, Sun Q, Liu W, Xu W, Denoble P, Tao H, Sun X.: Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. J Biomed Biotechnol. 2011;2011:305086.

(95)　Zhao L, Zhou C, Zhang J, Gao F, Li B, Chuai Y, Liu C, Cai J.: Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice. Int J Biol Sci. 2011;7(3):297-300.

(96)　Huang CS, Kawamura T, Peng X, Tochigi N, Shigemura N, Billiar TR, Nakao A, Toyoda Y.: Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochem Biophys Res Commun. 2011;408(2):253-8.

(97)　Chen H., Sun YP, Hu PF, Liu WW, Xiang HG, Li Y, Yan RL, Su N, Ruan CP, Sun XJ, Wang Q.: The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. J Surg Res. 2011 ;167(2):316-22.

(98)　Wang F, Yu G, Liu SY, Li JB, Wang JF, Bo LL, Qian LR, Sun XJ, Deng XM.: Hydrogen-rich saline protects against renal ischemia/reperfusion injury in rats. J Surg Res. 2011;167(2):e339-44.

(99)　Ohta S, Nakao A, and Ohno K. The 2011 Medical Molecular Hydrogen Symposium: An Inaugural Symposium of the Journal Medical Gas Research.　Med Gas Res. 2011, 1:10 .

(100)　大野欽司：分子状水素のサイエンス　ANITI-AGING MEDICINE.2011;7(3):058(378)-67(87).

（上へ）

(101)　Ohta S: Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications.Current Pharmaceutical Design2011; (22):2241-52.

(102)　Ohta S.: Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases. Biochim Biophys Acta. 2011;1820(5);586-94.

(103)　Nakai Y, Sato B, Ushiama S, Okada S, Abe K, Arai S.: Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water.Biosci Biotechnol Biochem./ 2011;75(4):774-6.

(104)　Ji Q, Hui K, Zhang L, Sun X, Li W, Duan M.: The effect of hydrogen-rich saline on the brain of rats with transient ischemia.J Surg Res. 2011;168(1):e95-101.

(105)　Yu P, Wang Z, Sun X, Chen X, Zeng S, Chen L, Li S.: Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. Biochem Biophys Res Commun. 2011;409(2):350-5.

(106)　Ono H, Nishijims Y, Adachi N, Tachibana S, Chitoku S, Mukaihara S, Sakamoto M, Kudo Y, Nakazawa J, Kaneko K, Nawashiro H.: Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study. Med Gas Res. 2011; 1:12.

(107)　Eckermann JM, Chen W, Jadhav V, Hsu FP, Colohan AR, Tang J, Zhang JH: Hydrogen is neuroprotective against surgically induced brain injury. Med Gas Res. 2011;1(1):7.

(108)　Kang KM, Kang YN, Choi IB, Gu Y, Kawamura T, Toyoda Y, Nakao A.: Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Med Gas Res. 2011;1(1):11.

(109)　Liu Y, Liu W, Sun X, Li R, Sun Q, Cai J, Kang Z, Shijun Lv S, Zhang JH. and Zhang W.:Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model. Med Gas Res. 2011;1:15.

(110)　Terasaki Y, Ohsawa I, Terasak M, Takahashi M, Kunugi S, Dedong K, Urushiyama H, Amenomori1 S, Kaneko-Togashi M, Kuwahara N, Ishikawa A, Kamimura N, Ohta S, and Fukuda Y.: Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physio. Lung Cellular and Mol. Physio. 2011;301(4):L415-26.

(111)　Hanaoka T, Kamimura N, Yokota T, Takai S and Oht S: Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide. Med Gas Res. 2011;1-18.

(112)　Hugyecz M, Mracskó E, Hertelendy P, Farkas E, Domoki F, Bari F.: Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Brain Res. 2011;1404:31-8.

(113)　Itoh T, Hamada N, Terazawa R, Ito M, Ohno K, Ichihara M, Nozawa Y, Ito M.: Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages. Biochem Biophys Res Commun. 2011;411(1):143-9.

(114)　Zhu WJ, Nakayama M, Mori T, Nakayama K, Katoh J, Murata Y, Sato T, Kabayama S, Ito S.: Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats. Nephrol Dial Transplant. 2011;26(7):2112-8.

(115)　Ni XX, Cai ZY, Fan DF, Liu Y, Zhang RJ, Liu SL, Kang ZM, Liu K, Li RP, Sun XJ, Xu WG.: Protective effect of hydrogen-rich saline on decompression sickness in rats. Aviat Space Environ Med. 2011 ;82(6):604-9.

(116)　Shen Y, Yang T, Wang T, Wen F.: Hydrogen gas: A novel antioxidant for chronic obstructive pulmonary disease? J. Med. Colleges of PLA. 2011;26 (2):94-7.

(117)　Song G, Tian H, Liu J, Zhang H, Sun X, Qin S.: H2 inhibits TNF-a-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor jB activation in endothelial cell. Biotechnol Lett. 2011;33(9):1715-22.

(118)　Shen L, Wang J, Liu K, Wang C, Wang C, Wu H, Sun Q, Sun X, Jing H.：Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest. Neurochem Res. 2011;36(8):1501-11.

(119)　Buchholz BM, Masutani, K, Kawamura T, Peng X, Toyoda Y, Billiar TR, Bauer AJ, and Nakao A.: Hydrogen-Enriched Preservation Protects the Isogeneic Intestinal Graft and Amends Recipient Gastric Function During Transplantation. Transplantation 2011;92(9):985-92.

(120)　Hayashi T, Yoshioka T, Hasegawa K, Miyamura M, Mori T, Ukimura A, Matsumura Y, Ishizaka N.: Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice. Am J Physiol Heart Circ Physiol. 2011;301(3):H1062-9.

(121)　Yang X, Guo L, Sun X, Chen X, Tong X.: Protective effects of hydrogen-rich saline in preeclampsia rat model. Placenta. 2011;32(9):681-6.

(122)　Fujita K, Nakabeppu Y, Noda M.：Therapeutic effects of hydrogen in animal models of Parkinson’s disease. Parkinsons Dis. 2011;2011:307875.

(123)　Fujita R, Tanaka Y, Saihara Y, Yamakita M, Ando D, Koyama K.：Effect of molecular hydrogen saturated alkaline electrolyzed water on disuse muscle atrophy in gastrocnemius muscle. J Physiol Anthropol. 2011;30(5):195-201.

(124)　Noda M, Fujita K, Lee CH, Yoshioka T.: The Principle and the Potential Approach to ROS-Dependent Cytotoxicity by Non-Pharmaceutical Therapies: Optimal use of Medical Gases with Antioxidant Properties. Curr Pharm Des. 2011; 17(22):2253-63.

(125)　Matsushita T, Kusakabe Y, Kitamura A, Okada S, Murase K.: Investigation of protective effect of hydrogen-rich water against cisplatininduced nephrotoxicity innance imag rats using blood oxygenation level-dependent magnetic resoing. Jpn J Radiol．2011；29:503–12.

(126)　Kasuyama K, Tomofuji T, Ekuni D, Tamaki N, Azuma T, Irie K, Endo Y, Morita M.: Hydrogen-rich water attenuates experimental periodontitis in a rat model. J Clin Periodontol. 2011;38(12):1085-90.

(127)　Hashimoto M, Katakura M, Nabika T, Tanabe Y, Hossain S, Tsuchikura S, Shido O: Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat – a metabolic syndrome rat model. Med Gas Res.2011;1(1):26.

(128)　 Qiu X, Li H, Tang H, Jin Y, Li W, Yusun, Pingfeng, Sun X, Xia Z.: Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol. 2011;11(12):2130-7.

(129)　Lekic T, Manaenko A, Rolland W, Fathali N, Peterson M, Tang J, Zhang JH.: Protective effect of hydrogen gas therapy after germinal matrix hemorrhage in neonatal rats. Acta Neurochir Suppl. 2011;111:237-41.

(130)　Manaenko A, Lekic T, Ma Q, Ostrowski RP, Zhang JH, Tang J.: Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage. Acta Neurochir Suppl. 2011;111:179-83.

(131)　Chen, J., Li, M., Zhang, B., Xiao, H., Qi, T., Sun, X., Chen, X.: Hydrogen therapy may be a novel, safe and effective treatment for infertility patients with varicocele. Scientific Res. Essays 2011;6 (30):6246-9.

(132)　Ito M, Ibi T, Sahashi K, Ichihara M, Ito M, Ohno K.: Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. Med Gas Res. 2011;1(1):24.

(133)　Tang XQ, Chen RQ, Ren YK, Soldato PD, Sparatore A, Zhuang YY, Fang HR, Wang CY.: ACS6, a Hydrogen sulfide-donating derivative of sildenafil, inhibits homocysteine-induced apoptosis by preservation of mitochondrial function. Med Gas Res. 2011;1(1):20.

(134)　Nakao A, Toyoda Y.: Book Review: Gas Biology Research in Clinical Practice, edited by Toshikazu Yoshikawa and Yuji Naito. Med Gas Res. 2011;1(1):25.

(135)　Liu W, Khatibi N, Sridharan A, Zhang JH.: Application of medical gases in the field of neurobiology. Med Gas Res. 2011;1(1):13.

(136)　Kohno M, Mokudai T, Ozawa T, Niwano Y.：Free radical formation from sonolysis of water in the presence of different gases. J Clin Biochem Nutr. 2011;49(2):96-101.

(137)　Liu SL, Liu K, Sun Q, Liu WW, Tao HY, Sun XJ.: Hydrogen therapy may be a novel and effective treatment for COPD. Front Pharmacol. 2011 ;2:19.

(138)　Matsushita T, Kusakabe Y, Kitamura A, Okada S, Murase K.: Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging. Magn Reson Med Sci. 2011;10(3):169-76.

(139)　Chuai Y, Zhao L, Ni J, Sun D, Cui J, Li B, Qian L, Gao F, Cai J.: A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution. Med Sci Monit. 2011;17(4):HY1-4.

(140)　Fang Y, Fu XJ, Gu C, Xu P, Wang Y, Yu WR, Sun Q, Sun XJ, Yao M.: Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. J Burn Care Res. 2011;32(3):e82-91.

(141)　Liu W, Chen O, Chen C, Wu B, Tang J, Zhang JH.: Protective effects of hydrogen on fetal brain injury during maternal hypoxia. Acta Neurochir Suppl. 2011;111:307-11.

(142)　Yoon KS, Huang XZ, Yoon YS, Kim SK, Song SB, Chang BS, Kim DH, Lee KJ.: The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice. Biol Pharm Bull. 2011;34(11):1671-7.

(143)　Schoenfeld MP, Ansari RR, Nakao A, Wink D.: A hypothesis on biological protection from space radiation through the use of new therapeutic gases. Med Gas Res. 2012;2:8.

(144)　 Kato S, Saitoh Y, Iwai K, Miwa N.: Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocyte. J Photochem Photobiol B. 2012;106:24-33.

(145)　Qu J, Li X, Wang J, Mi W, Xie K, Qiu J.: Inhalation of hydrogen gas attenuates cisplatin-induced ototoxicity via reducing oxidative stress. Int J Pediatr Otorhinolaryngol. 2012 ;76(1):111-5.

(146)　Wei L, Ge L, Qin S, Shi Y, Du C, Du H, Liu L, Yu Y, Sun X.: Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injuryin guinea pig. Exp Eye Res. 2012;94(1):117-27.

(147)　Chen X, Zhai X, Kang Z, Sun X.: Lactulose: an effective preventive and therapeutic option for ischemic stroke by production of hydrogen. Med Gas Res. 2012;2(1):3.

(148)　Seo T, Kurokawa R, Sato B.: A Convenient Method for Determining the Concentration of Hydrogen in Water: Use of Methylene Blue with Colloidal Platinum. Med Gas Res. 2012;2(1):1.

(149)　Chuai Y, Gao F, Li B, Zhao L, Qian L, Cao F, Wang L, Sun X, Cui J, Cai J.: Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals. Biochem J. 2012;442(1):49-56.

(150)　Song G, Tian H, Qin S, Sun X, Yao S, Zong C, Luo Y, Liu J, Yu Y, Sang H, Wang X : Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice. Atherosclerosis. 2012;221(1):55-65.

(151)　Nishimura N, Tanabe H, Sasaki Y, Makita Y, Ohata M, Yokoyama S, Asano M, Yamamoto T, Kiriyama S.: Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischaemia–reperfusion injury in rats. Br J Nutr. 2012;107(4):485-92.

(152)　Zhou Y, Zheng H, Ruan F, Chen X, Zheng G, Kang M, Zhang Q, Sun X. : Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs. Neurosci. 2012; 209:47-53.

(153)　Li H, Zhou R, Liu J, Li Q, Zhang J, Mu J, Sun X.: Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits. J Surg Res. 2012;174(1):e11-6.

(154)　Sun Q, Kawamura T, Masutani K, Peng X, Sun Q, Stolz DB, Pribis JP, Billiar TR, Sun X, Bermudez CA, Toyoda Y, Nakao A: Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats. Cardiovasc Res. 2012;94(1):144-53.

(155)　Zheng H, Yu YS.:Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats. Biochem Pharmacol. 2012;83(9):1269-77.

(156)　Aoki K, Nakao A, Adachi T, Matsui Y and Miyakawa S: Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Med. Gas Res. 2012;2(1):12.

(157)　Eckermann JM, Krafft PR, Shoemaker L, Lieberson RE, Chang SD, Colohan A.: Potential application of hydrogen in traumatic and surgical brain injury, stroke and neonatal hypoxia-ischemia. Med Gas Res. 2012;2(1):11.

(158)　Yoshida A, Asanuma H, Sasaki H, Sanada S, Yamazaki S, Asano Y, Shinozaki Y, Mori H, Shimouchi A, Sano M, Asakura M, Minamino T, Takashima S, Sugimachi M, Mochizuki N, Kitakaze M.: H2 Mediates Cardioprotection Via Involvements of KATP Channels and Permeability Transition Pores of Mitochondria in Dogs. Cardiovasc Drugs Ther. 2012;26(3):217-26.

（上へ）

(159)　Yu YS, Zheng H.: Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. Mol Cell Biochem. 2012;365(1-2):233-42.

(160)　Xie K, Yu Y, Huang Y, Zheng L, Li J, Chen H, Han H, Hou L, Gong G, Wang G.: Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock. 2012;37(5):548-55.

(161)　Ito M, Hirayama M, Yamai K, Goto S, Ito M, Ichihara M, Ohno K.: Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats. Med Gas Res. 2012;2(1):15.

(162)　Ono H, Nishijima Y, Adachi N, Sakamoto M, Kudo Y, Nakazawa J, Kaneko K..: Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers. Med Gas Res. 2012;2(1):14.

(163)　Zhuang Z, Zhou ML, You WC, Zhu L, Ma CY, Sun XJ, Shi JX.: Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. BMC Neurosci. 2012;13(1):47.

(164)　Ekuni D, Tomofuji T, Endo Y, Kasuyama K, Irie K, Azuma T, Tamaki N, Mizutani S, Kojima A, Morita M.: Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model. Arch Oral Biol.2012; 57(12):1615-22.

(165)　Kawai D, Takaki A, Nakatsuka A, Wada J, Tamaki N, Yasunaka T, Koike K, Tsuzaki R, Matsumoto K, Miyake Y, Shiraha H, Morita M, Makino H, Yamamoto K.: Hydrogen-rich water prevents progression of non-alcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice.　 Hepatology.2012;56(3):912-21.

(166)　Zhou J, Chen Y, Huang GQ, Li J, Wu GM, Liu L, Bai YP, Wang J.: Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture. J Surg Res.2012;178(1)390-400.

(167)　Zong C, Song G, Yao S, Li L, Yu Y, Feng L, Guo S, Luo T, Qin S.: Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters. Metabolism. 2012;61(6):794-800.

(168)　Sakai K, Cho S, Shibata I, Yoshitomi O, Maekawa T, Sumikawa K.: Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine. Scand Cardiovasc J. 2012;46(3):183-9.

(169)　Nagatani K, Wada K, Takeuchi S, Kobayashi H, Uozumi Y, Otani N, Fujita M, Tachibana S, Nawashiro H.: Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia. Shock. 2012;37(6):645-52.

(170)　Jiang D, Wu D, Zhang Y, Xu B, Sun X, Li Z.: Protective effects of hydrogen rich saline solution on experimental testicular ischemia-reperfusion injury in rats. J Urol.2012;187(6):2249-53.

(171)　Lee JW, Kim JI, Lee YA, Lee DH, Song CS, Cho YJ, Han JS.: Inhaled hydrogen gas therapy for prevention of testicular ischemia/reperfusion injury in rats. J Pediatr Surg.2012;47(4):736-42.

(172)　Hong Y, Guo S, Chen S, Sun C, Zhang J, Sun X.: Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid hemorrhage in rats. J Neurosci Res. 2012; 90(8):1670-80.

(173)　Huang L, Zhao S, Zhang JH, Sun X.: Hydrogen saline treatment attenuates hyperoxia-induced retinopathy by inhibition of oxidative stress and reduction of VEGF expression. Ophthalmic Res. 2012;47(3):122-7.

(174)　Qin ZX, Yu P, Qian DH, Song MB, Tan H, Yu Y, Li W, Wang H, Liu J, Wang Q, Sun XJ, Jiang H, Zhu JK, Lu W, Huang L.: Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-α/NF-κB pathway. Atherosclerosis. 2012;220(2):343-50.

(175)　Shi P, Sun W, Shi P.: A hypothesis on chemical mechanism of the effect of hydrogen. Med Gas Res. 2012;21;2(1):17.

(176)　Kagawa A, Katsura K, Mizumoto M, Tagawa Y, Masiko Y.: Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells. Materials Science Forum 2012;706-709:520-5.

(177)　Nie W, Tang H, Fang Z, Chen J, Chen H, Xiu Q.: Hydrogenase: The next antibiotic target? Clin Sci (Lond).2012;122(12):575-80.

(178)　Hou Z, Luo W, Sun X, Hao S, Zhang Y, Xu F, Wang Z, Liu B.: Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury. Brain Res Bull.2012;88(6):560-5.

(179)　Abe T, Li XK, Yazawa K, Hatayama N, Xie L, Sato B, Kakuta Y, Tsutahara K, Okumi M, Tsuda H, Kaimori JY, Isaka Y, Natori M, Takahara S, Nonomura N: Hydrogen-rich university of wisconsin solution attenuates renal cold ischemia-reperfusion injury. Transplantation. 2012;94(1):14-21.

(180)　Wang QJ, Zha XJ, Kang ZM, Xu MJ, Huang Q, Zou DJ.: Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress. Chin Med J (Engl).2012;125(9):1633-7.

(181)　Ohno K, Ito M, Ichihara M, Ito M.: Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxid Med Cell Longev. 2012; 2012:353152.

(182)　Takeuchi S, Wada K, Nagatani K, Osada H, Otani N, Nawashiro H.: Hydrogen may inhibit collagen-induced platelet aggregation: An ex vivo and in vivo study. Intern Med. 2012;51(11):1309-13.

(183)　Ghanizadeh A.: Physical exercise and intermittent administration of lactulose may improve autism symptoms through hydrogen production. Med Gas Res.2012;2(1):19.

(184)　Katakura M, Hashimoto M, Tanabe Y, Shido O.: Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney. Med Gas Res. 2012;2(1):18.

(185)　Shi J, Yao F, Zhong C, Pan X, Yang Y, Lin Q.: Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries in rats. Heart Lung Circ. 2012;21(9):556-63.

(186)　Spulber S, Edoff K, Hong L, Morisawa S, Shirahata S, Ceccatelli S.: Molecular hydrogen reduces lps-induced neuroinflammation and promotes recovery from sickness behaviour in mice. PLoS One.2012;7(7):e42078.

(187)　Ono H, Nishijima Y, Adachi N, Sakamoto M, Kudo Y, Kaneko K, Nakao A, Imaoka T.:A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level. Med Gas Res. 2012;2(1):21.

(188)　Zhang J, Liu C, Tai M, Qu K. : Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia (Shock 37(6), 645-652, 2012). Shock.2012;38(4):444.

(189)　Ren J, Luo Z, Tian F, Wang Q, Li K, Wang C.: Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats. J Trauma Acute Care Surg.2012;72(6):1555-61.

(190)　Faller S, Zimmermann KK, Strosing KM, Engelstaedter H, Buerkle H, Schmidt R, Spassov SG and Hoetzel A: Inhaled hydrogen sulfide protects against lipopolysaccharide-induced acute lung injury in mice. Med Gas Res. 2012;2(1):26.

(191)　Ishibashi T, Sato B, Rikitake M, Seo T, Kurokawa R, Hara Y, Naritomi Y, Hara H, Nagao T.: Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Med Gas Res. 2012;2(1):27.

(192)　Zhang JY, Liu C, Zhou L, Qu K, Wang R, Tai MH, Lei Lei JC, Wu QF, Wang ZX: A review of hydrogen as a new medical therapy. Hepatogastroenterology. 2012;59(116):1026-32.

(193)　Xu Z, Zhou J, Cai J, Zhu Z, Sun X, Jiang C.: Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema. J Inflamm (Lond). 2012; 2;9:2.

(194)　Fujita K, Yamafuji M, Nakabeppu Y, Noda M.: Therapeutic approach to neurodegenerative diseases by medical gases: Focusing on redox signaling and related antioxidant enzymes. Oxid Med Cell Longev. 2012;324256.

(195)　Ghanizadeh, A.: Hydrogen as a novel hypothesized emerging treatment for oxidative stress in autism. European Review for Medical and Pharmacological Sciences. 2012;16 (9):1313-4.

(196)　Zhang JY, Liu C.: Letter to the Editor on ” Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement” . Biochem Biophys Res Commun. 2012;427(1):227.

(197)　Xiang L, Tan JW, Huang LJ, Jia L, Liu YQ, Zhao YQ, Wang K, Dong JH.: Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine. World J Gastroenterol. 2012;18(37):5197-204.

(198)　Ji X, Tian Y, Xie K, Liu W, Qu Y, Fei Z.: Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress. J Surg Res. 2012;178(1):e9-16.

(199)　Xie Y, Mao Y, Lai D, Zhang W, Shen W.: H(2) Enhances Arabidopsis Salt Tolerance by Manipulating ZAT10/12-Mediated Antioxidant Defence and Controlling Sodium Exclusion. PLoS One. 2012;7(11):e49800.

(200)　Li J, Dong Y, Chen H, Han H, Yu Y, Wang G, Zeng Y, Xie K.: Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines. Brain Res. 2012;1486:103-11.

（上へ）

(201)　Yang Y, Li B, Liu C, Chuai Y, Lei J, Gao F, Cui J, Sun D, Cheng Y, Zhou C, Cai J: Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis. Med Sci Monit. 2012;18(4):BR144-8.

(202)　Hardeland R Dr.:Hydrogen therapy: A future option in critical care? Crit Care Med. 2012;40(4):1382-3.

(203)　Zhan Y, Chen C, Suzuki H, Hu Q, Zhi X, Zhang JH.: Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. Crit Care Med. 2012 ;40(4):1291-6.

(204)　Chuai Y, Shen J, Qian L, Wang Y, Huang Y, Gao F, Cui J, Ni J, Zhao L, Liu S, Sun X, Li B, Cai J.: Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. Med Sci Monit. 2012;18(3):BR89-94.

(205)　Qu J, Gan YN, Xie KL, Liu WB, Wang YF, Hei RY, Mi WJ, Qiu JH. : Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils. Acta Pharmacol Sin. 2012;33(4):445-51.

(206)　Zhou J, Wu PF, Wang F, Chen JG.: Targeting gaseous molecules to protect against cerebral ischaemic injury: Mechanisms and prospects. Clin Exp Pharmacol Physiol.2012;39(6):566-76.

(207)　Qian L, Shen J, Cai J. ：Hydrogen therapy may be an effective and specific novel treatment for aplastic anemia. Med Sci Monit. 2012;18(6):HY19-22.

(208)　Simon AR.: Hydrogen-supplemented drinking water, just soda or an elixir of life?*. Transpl Int. 2012;25(12):1211-2.

(209)　Xie K, Fu W, Xing W, Li A, Chen H, Han H, Yu Y, Wang G.: Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis. Shock 2012;38 (6): 656-63.

(210)　Noda K, Tanaka Y, Shigemura N, Kawamura T, Wang Y, Masutani K, Sun X, Toyoda Y, Bermudez CA, Nakao A.: Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transpl Int. 2012;25(12):1213-22.

(211)　Guo Z, Zhou B, Li W, Sun X, Luo D.: Hydrogen – rich saline protects against ultraviolet B radiation injury in rats. J Biomed Res. 2012;26(5):365-71.

(212)　Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Maekawa Y, Kawamura A, Abe T, Ohta S, Fukuda K, Hori S.: H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. J Am Heart Assoc. 2012;1(5):e003459.

(213)　大澤郁朗：水素分子の生理作用と水素水による疾患防御. 日本老年医学誌 2012;49(6)680-8.

(214)　佐藤泰司：発達期の脳とセボフルラン．日本麻酔科学会第59回学術集会共催セミナー　2012.

(215)　Yonamine R, Satoh Y, Kodama M, Araki Y, Kazama T.: Coadministration of Hydrogen Gas as Part of the Carrier Gas Mixture Suppresses Neuronal Apoptosis and Subsequent Behavioral Deficits Caused by Neonatal Exposure to Sevoflurane in Mice. Anesthesiology. 2013;118(1):105-13.

(216)　Cai WW, Zhang MH, Yu YS, Cai JH.: Treatment with hydrogen molecule alleviates TNFα-induced cell injury in osteoblast. Mol Cell Biochem. 2013;373(1-2):1-9.

(217)　Wang W, Tian L, Li Y, Wang X, Xia F, Li L, Li J, Zhang Z.:Effects of Hydrogen-rich Saline on Rats with Acute Carbon Monoxide Poisoning. J Emerg Med. 2013;44(1):107-15.

(218)　Amitani H, Asakawa A, Cheng K, Amitani M, Kaimoto K, Nakano M, Ushikai M, Li Y, Tsai M, Li JB, Terashi M, Chaolu H, Kamimura R, Inui A.: Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle. PLoS One. 2013;8(1):e53913.

(219)　Li GM, Ji MH, Sun XJ, Zeng QT, Tian M, Fan YX, Li WY, Li N, Yang JJ.: Effects of hydrogen-rich saline treatment on polymicrobial sepsis. J Surg Res. 2013;181(2):279-86.

(220)　Huang G, Zhou J, Zhan W, Xiong Y, Hu C, Li X, Li X, Li Y, Liao X.: The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest. Resuscitation.2013v;84(5):690-5.

(221)　Shen MH, Cai JM, Sun Q, Zhang DW, Huo ZL, He J, Sun XJ.: Neuroprotective effect of hydrogen-rich saline in acute carbon monoxide poisoning. CNS Neurosci Ther. 2013;19(5):361-3.

(222)　Manaenko A, Lekic T, Ma Q, Zhang JH, Tang J.: Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. Crit Care Med. 2013;41(5):1266-75.

(223)　Zhao L, Wang YB, Qin SR, Ma XM, Sun XJ, Wang ML, Zhong RG.: Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap. J Zhejiang Univ Sci B. 2013;14(5):382-91.

(224)　Jin Q, Zhu K, Cui W, Xie Y, Han B, Shen W.:Hydrogen gas acts as a novel bioactive molecule in enhancing plant tolerance to paraquat-induced oxidative stress via the modulation of heme oxygenase-1 signalling system. Plant Cell Environ. 2013;36(5):956-69.

(225)　Shin MH, Park R, Nojima H, Kim HC, Kim YK, Chung JH.: Atomic Hydrogen Surrounded by Water Molecules, H(H2O)m, Modulates Basal and UV-Induced Gene Expressions in Human Skin In Vivo. PLoS One. 2013;8(4):e61696.

(226)　Tsubone H, Hanafusa M, Endo M, Manabe,N, Hiraga A, Ohmura H, Aida H.: Effect of treadmill exercise and hydrogen-rich water intake on serum oxidative and anti-oxidative metabolites in serum of thoroughbred horses. J Equine Sci. 2013;24 (1) 1-8.

(227)　Chang WJ, Toledo-Pereyra LH.: The potential benefits of hydrogen-rich saline in ischemia and reperfusion injury. J Surg Res. 2013;180(2):248-9.

(228)　Guo JD, Li L, Shi YM, Wang HD, Hou SX.:Hydrogen water consumption prevents osteopenia in ovariectomized rats. Br J Pharmacol. 2013;168(6):1412-20.

(229)　Ignacio RM, Yoon YS, Sajo EJ, Kim CS, Kim DH, Kim SK, Lee KJ.: The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice. Molecular and Cellular Toxicol. 2013;9(1):15-21.

(230)　Liu W, Shan LP, Dong XS, Liu XW, Ma T, Liu Z.: Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. World J Gastroenterol. 2013;19(4):492-502.

(231)　Fujii Y, Shirai M, Inamori S, Shimouchi A, Sonobe T, Tsuchimochi H, Pearson JT, Takewa Y, Tatsumi E, Taenaka Y.: Insufflation of Hydrogen Gas Restrains the Inflammatory Response of Cardiopulmonary Bypass in a Rat Model. Artif Organs. 2013;37(2):136-41.

(232)　Matsumoto S, Ueda T, Kakizaki H.: Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome. Urology. 2013;81(2):226-30.

(233)　Dixon BJ, Tang J, Zhang JH.: The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance. Med Gas Res. 2013;3(1):10.

(234)　Iio A, Ito M, Itoh T, Terazawa R, Fujita Y, Nozawa Y, Ohsawa I, Ohno K, Ito M.: Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells. Med Gas Res. 2013;3(1):6.

(235)　Noda K, Shigemura N, Tanaka Y, Kawamura T, Hyun Lim S, Kokubo K, Billiar TR, Bermudez CA, Kobayashi H, Nakao A.: A novel method of preserving cardiac grafts using a hydrogen-rich water bath. J Heart Lung Transplant. 2013;32(2):241-50.

(236)　Feng Y, Wang R, Xu J, Sun J, Xu T, Gu Q, Wu X.: Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats. Current Eye Research 2013;38 (3):396-404.

(237)　Chen Y, Jiang J, Miao H, Chen X, Sun X, Li Y.: Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways. Int J Mol Med. 2013;31(3):597-606.

(238)　Zhou H, Fu Z, Wei Y, Liu J, Cui X, Yang W, Ding W, Pan P, Li W.: Hydrogen inhalation decreases lung graft injury in brain-dead donor rats. J Heart Lung Transplant. 2013;32(2):251-8.

(239)　Yoritaka A, Takanashi M, Hirayama M, Nakahara T, Ohta S, Hattori N.: Pilot Study of H2 Therapy in Parkinson’s Disease: A Randomized Double-Blind Placebo-Controlled Trial. Mov Disord. 2013;28(6):836-9.

(240)　Fan M, Xu X, He X, Chen L, Qian L, Liu J, Qing J, Chao Z, Sun X.: Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model. J Urol. 2013;190(1):350-6.

(241)　Kawamura T, Wakabayashi N, Shigemura N, Huang CS, Masutani K, Tanaka Y, Noda K, Peng X, Takahashi T, Billiar TR, Okumura M, Toyoda Y, Kensler TW, Nakao A.: Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol. 2013;304(10):L646-56.

(242)　Sun Y, Shuang F, Chen DM, Zhou RB.: Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats. Osteoporos Int. 2013;24(3):969-78.

(243)　Tan M, Sun X, Guo L, Su C, Sun X, Xu Z.: Hydrogen as additive of HTK solution fortifies myocardial preservation in grafts with prolonged cold ischemia. Int J Cardiol. 2013;167(2):383-90.

(244)　Song G, Li M, Sang H, Zhang L, Li X, Yao S, Yu Y, Zong C, Xue Y, Qin S.: Hydrogen -rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. J Lipid Res. 2013 ;54(7):1884-93.

(245)　Nagatani K, Nawashiro H, Takeuchi S, Tomura S, Otani N, Osada H, Wada K, Katoh H, Tsuzuki N, Mori K.: Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies. Med Gas Res. 2013 ;3(1):13.

(246)　 Terawaki H, Hayashi Y, Zhu WJ, Matsuyama Y, Terada T, Kabayama S, Watanabe T, Era S, Sato B, Nakayama M.: Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity. Med Gas Res. 2013;3(1):14.

(247)　Liu GD, Zhang H, Wang L, Han Q, Zhou SF, Liu P.: Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells. Int J Ophthalmol. 2013;6(3):280-5.

(248)　Shinbo T, Kokubo K, Sato Y, Hagiri S, Hataishi R, Hirose M, Kobayashi H.: Breathing Nitric Oxide plus Hydrogen Gas Reduces Ischemia-Reperfusion Injury and Nitrotyrosine Production in Murine Heart. Am J Physiol Heart Circ Physiol.2013;305(4):H542-50.

(249)　Chen X, Zhai X, Shi J, Liu WW, Tao H, Sun X, Kang Z.: Lactulose mediates suppression of dextran sodium sulfate-induced colon inflammation by increasing hydrogen production. Dig Dis Sci.2013;58(6):1560-8.

(250)　Cui W, Gao C, Fang P, Lin G, Shen W.: Alleviation of cadmium toxicity in Medicago sativa by hydrogen-rich water. J Hazard Mater. 2013;260C:715-24.

(251)　Zhang DQ, Feng H, Chen WC.: Effects of hydrogen-rich saline on taurocholate-induced acute pancreatitis in rat. Evid Based Complement Alternat Med. 2013;2013:731932.

（上へ）

(252)　Zeng J, Zhang M, Sun X.: Molecular hydrogen is involved in phytohormone signaling and stress responses in plants. PLoS One. 2013;8(8):e71038.

(253)　Ostrowski RP, Pucko EB.: Research of medical gases in Poland. Med Gas Res. 2013;3(1):17.

(254)　Tian L, Zhang L, Xia F, An J, Sugita Y and Zhang Z : Hydrogen-rich saline ameliorates the retina against light-induced damage in rats. Med Gas Res. 2013; 3(1):19.

(255)　Xu S, Zhu S, Jiang Y, Wang N, Wang R, Shen W, Yang J.: Hydrogen-rich water alleviates salt stress in rice during seed germination. Plant and Soil 2013;370(1-2) :47-57.

(256)　He B, Zhang Y, Kang B, Xiao J, Xie B, Wang Z.: Protection of oral hydrogen water as an antioxidant on pulmonary hypertension. Mol Biol Rep. 2013 ;40(9):5513-21.

(257)　 Sheng Q, Lv Z, Cai W, Song H, Qian L, Wang X.: Protective effects of hydrogen-rich saline on necrotizing enterocolitis in neonatal rats. J Pediatr Surg.2013;48(8):1697-706.

(258)　Oláh O, Tóth-Szűki V, Temesvári P, Bari F, Domoki F.: Delayed neurovascular dysfunction is alleviated by hydrogen in asphyxiated newborn pigs. Neonatology. 2013;104(2):79-86.

(259)　Yang CX, Yan H, Ding TB.: Hydrogen saline prevents selenite-induced cataract in rats. Mol Vis. 2013;19:1684-93.

(260)　Matsuzaki M, Kagawa A, Motoishi A, Tanaka K,Yamamoto M, Tagawa Y.: Mechanism of cancer cell death induced by hydrogen discharged from palladium base hydrogen storage alloy. Advanced Materials Research 2013;699: 284-90.

(261)　Matsumoto A, Yamafuji M, Tachibana T, Nakabeppu Y, Noda M, Nakaya H.: Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice. Sci Rep. 2013;3:3273.

(262)　Zhuang Z, Sun XJ, Zhang X, Liu HD, You WC, Ma CY, Zhu L, Zhou ML, Shi JX.: Nuclear factor-κB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits. J Neurosci Res.2013;91(12):1599-608.

(263)　Ishibashi T.: Molecular hydrogen: New antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases. Curr Pharm Des. 2013;19(35):6375-81.

(264)　He J, Xiong S, Zhang J, Wang J, Sun A, Mei X, Sun X, Zhang C, Wang Q.: Protective effects of hydrogen-rich saline on ulcerative colitis rat model. J Surg Res.2013;185(1):174-81.

(265)　Qian L, Shen J, Chuai Y, Cai J.: Hydrogen as a new class of radioprotective agent. Int J Biol Sci. 2013;9(9):887-94.

(266)　Zhai X, Chen X, Shi J, Shi D, Ye Z, Liu W, Li M, Wang Q, Kang Z, Bi H, Sun X.: Lactulose ameliorates cerebral ischemia-reperfusion injury in ratsby inducing hydrogen by activating Nrf2 expression. Free Radic Biol Med. 2013;65C:731-41.

(267)　Zhao S, Mei K, Qian L, Yang Y, Liu W, Huang Y, Zhang C, Sun X, Liu C, Li B, Gao F, Cai J, Ni J.: Therapeutic effects of hydrogen-rich solution on aplastic anemia in vivo. Cell Physiol Biochem.2013;32(3):549-60.

(268)　Akdeniz E, Bostanci Y, Özden E, Meydan BC, Yilmaz AF, Sarikaya Ş, Yakupoǧlu YK.:Inhaled Hydrogen Gas Therapy for Prevention of Renal Ischemia/Reperfusion Injury in Rat Model. Turkiye Klinikleri J. Med. Sci. 2013; 33 (4):1097-102.

(269)　Chen Q, Chen P, Zhou S, Yan X, Zhang J, Sun X, Yuan H, Yu W.: Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. Can J Neurol Sci. 2013;40(6):857-63.

(270)　Xiao M, Zhu T, Wang T, Wen FQ.: Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma. Eur Rev Med Pharmacol Sci. 2013;17(8):1033-43.

(271)　Ning Y, Shang Y, Huang H, Zhang J, Dong Y, Xu W, Li Q.: Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats. PLoS One. 2013;8(12):e83429.

(272)　Ignacio RM, Kwak HS, Yun YU, Sajo ME, Yoon YS, Kim CS, Kim SK, Lee KJ.: The drinking effect of hydrogen water on atopic dermatitis induced by Dermatophagoides farinae allergen in NC/Nga mice. Evid Based Complement Alternat Med. 2013;2013:538673.

(273)　Zhu WJ, Nakayama M, Mori T, Hao K, Terawaki H, Katoh J, Kabayama S, Ito S.: Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water. Med Gas Res. 2013;3(1):26.

(274)　Li Q, Kato S, Matsuoka D, Tanaka H, Miwa N.: Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro. Med Gas Res. 2013;3(1):20.

(275)　Koyama Y, Taura K, Hatano E, Tanabe K, Yamamoto G, Nakamura K, Yamanaka K, Kitamura K, Narita M, Nagata H, Yanagida A, Iida T, Iwaisako K, Fujinawa H, Uemoto S.: Effects of oral intake of hydrogen water on liver fibrogenesis in mice. Hepatol Res.2014;44(6):663-677.

(276)　Gu H, Yang M, Zhao X, Zhao B, Sun X, Gao X.: Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats. J Surg Res. 2014;188(1):243-9.

(277)　Mano Y, Kotani T, Ito M, Nagai T, Ichinohashi Y, Yamada K, Ohno K, Kikkawa F, Toyokuni S.: Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion. Free Radic Biol Med. 2014;69:324-30.

(278)　Zhang JY, Wu QF, Wan Y, Song SD, Xu J, Xu XS, Chang HL, Tai MH, Dong YF, Liu C.: Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats. World J Gastroenterol. 2014;20(6):1614-22.

(279)　Liu Y, Yang L, Tao K, Vizcaychipi MP, Lloyd DM, Sun X, Irwin MG, Ma D, Yu W.: Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release. BMC Gastroenterol. 2014;14(1)12.

(280)　Matsuno N, Watanabe R, Kimura M, Iwata S, Fujiyama M, Kono S, Shigeta T, Enosawa S.: Beneficial effects of hydrogen gas on porcine liver reperfusion injury with use of total vascular exclusion and active venous bypass. Transplant Proc. 2014;46(4):1104-6.

(281)　Terawaki H, Zhu WJ, Matsuyama Y, Terada T, Takahashi Y, Sakurai K, Kabayama S, Miyazaki M, Itami N, Nakazawa R, Ito S, Era S, Nakayama M.: Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients. Hemodial Int. 2014;18(2):459-66.

(282)　Zhang J, Wu Q, Song S, Wan Y, Zhang R, Tai M, Liu C.: Effect of hydrogen-rich water on acute peritonitis of rat models. Int Immunopharmacol. 2014;21(1):94-101.

(283)　Mangus DB, Huang L, Applegate PM, Jason W Gatling JW, Zhang J, Applegate RL: A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (Part I – Protection via specific pathways) Med Gas Res. 2014, 4:9.

(284)　Xin HG, Zhang BB, Wu ZQ, Hang XF, Xu WS, Ni W, Zhang RQ, Miao XH.: Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats. Mol Cell Biochem. 2014;392(1-2):117-24.

(285)　Xue J, Shang G, Tanaka Y, Saihara Y, Hou L, Velasquez N, Liu W, Lu Y.: Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water. BMC Complement Altern Med. 2014;14:81.

(286)　Chen L, Yu N, Lu Y, Wu L, Chen D, Guo W, Zhao L, Liu M, Yang S, Sun X, Zhai S.: Hydrogen-Saturated Saline Protects Intensive Narrow Band Noise-Induced Hearing Loss in Guinea Pigs through an Antioxidant Effect. PLoS One. 2014;9(6):e100774.

(287)　Li S, Lu D, Zhang Y, Zhang Y.: Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice. J Assist Reprod Genet. 2014;31(1):109-14.

(288)　DU Z, Jia H, Liu J, Zhao X, Wang Y, Sun X.: Protective effects of hydrogen-rich saline in uncontrolled hemorrhagic shock. Exp Ther Med. 2014 ;7(5):1253-8.

(289)　Hong Y, Shao A, Wang J, Chen S, Wu H, McBride DW, Wu Q, Sun X, Zhang J.: Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: Possible role of the Akt/GSK3β signaling pathway. PLoS One. 2014;9(4):e96212.

(290)　Deng J, Lei C, Chen Y, Fang Z, Yang Q, Zhang H, Cai M, Shi L, Dong H, Xiong L.: Neuroprotective gases – Fantasy or reality for clinical use? Prog Neurobiol. 2014;115:210-45.

(291)　Ge Y, Wu F, Sun X, Xiang Z, Yang L, Huang S, Lu Z, Sun Y, Yu WF.: Intrathecal infusion of hydrogen-rich normal saline attenuates neuropathic pain via inhibition of activation of spinal astrocytes and microglia in rats. PLoS One. 2014;9(5):e97436.

(292)　Zhao S, Yang Y, Liu W, Xuan Z, Wu S, Yu S, Mei K, Huang Y, Zhang P, Cai J, Ni J, Zhao Y.: Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction. J Cell Mol Med. 2014;18(5):938-46.

(293)　Sun JC, Xu T, Zuo Q, Wang RB, Qi AQ, Cao WL, Sun AJ, Sun XJ, Xu J.: Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush. PLoS One. 2014;9(6):e99299.

(294)　 Kawaguchi M, Satoh Y, Otsubo Y, Kazama T.: Molecular hydrogen attenuates neuropathic pain in mice. PLoS One. 2014;9(6):e100352.

(295)　 Liu C, Kurokawa R, Fujino M, Hirano S, Sato B, Li XK.: Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes. Sci Rep. 2014;4:5485.

(296)　Tan YC, Xie F, Zhang HL, Zhu YL, Chen K, Tan HM, Hu BS, Yang JM, Tan JW.: Hydrogen-rich saline attenuates postoperative liver failure after major hepatectomy in rats. Clin Res Hepatol Gastroenterol. 2014;38(3):337-45.

(297)　Tomofuji T, Kawabata Y, Kasuyama K, Endo Y, Yoneda T, Yamane M, Azuma T, Ekuni D, Morita M.:Effects of hydrogen-rich water on aging periodontal tissues in rats. Sci Rep. 2014;4:5534.

(298)　Zhang L, Shu R, Wang C, Wang H, Li N, Wang G.: Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit membrane trafficking through GSK-3β in the DRG in rats. Brain Res Bull.2014;106:47-55.

(299)　Penna A, Wang DS, Yu J, Lecker I, Brown PM, Bowie D, Orser BA: Hydrogen peroxide increases GABAA receptor-mediated tonic current in hippocampal neurons. J Neurosci. 2014;34(32):10624-34.

(300)　Zeng J, Ye Z, Sun X.: Progress in the study of biological effects of hydrogen on higher plants and its promising application in agriculture. Med Gas Res. 2014;4:15.

（上へ）

(301)　Ishibashi T, Sato B, Shibata S, Sakai T, Hara Y, Naritomi Y, Koyanagi S, Hara H, Nagao T.: Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study. Int Immunopharmacol. 2014;21(2):468-73.

(302)　Liu FT, Xu SM, Xiang ZH, Li XN, Li J, Yuan HB, Sun XJ.: Molecular Hydrogen Suppresses Reactive Astrogliosis Related to Oxidative Injury during Spinal Cord Injury in Rats. CNS Neurosci Ther. 2014;20(8):778-86.

(303)　Huo TT, Zeng Y, Liu XN, Sun L, Han HZ, Chen HG, Lu ZH, Huang Y, Nie H, Dong HL, Xie KL, Xiong LZ.: Hydrogen-rich saline improves survival and neurological outcome after cardiac arrest and cardiopulmonary resuscitation in Rats. Anesth Analg. 2014;119(2):368-80.

(304)　Kikkawa YS, Nakagawa T, Taniguchi M, Ito J.: Hydrogen protects auditory hair cells from cisplatin-induced free radicals. Neurosci Lett. 2014;579:125-9.

(305)　Dohi K, Kraemer BC, Erickson MA, McMillan PJ, Kovac A, Flachbartova Z, Hansen KM, Shah GN, Sheibani N, Salameh T, Banks WA.: Molecular hydrogen in drinking water Protects against neurodegenerative changes induced by traumatic brain injury. PLoS One. 2014;9(9):e108034.

(306)　Takeuchi S, Mori K, Arimoto H, Fujii K, Nagatani K, Tomura S, Otani N, Osada H, Wada K.: Effects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: Study protocol for a randomized controlled trial. BMC Neurol. 2014;14:176.

(307)　Ohta S.: Molecular hydrogen as a preventive and therapeutic medical gas: Initiation, development and potential of hydrogen medicine. Pharmacol Ther. 2014;144(1):1-11.

(308)　Wang T, Zhao L, Liu M, Xie F, Ma X, Zhao P, Liu Y, Li J, Wang M, Yang Z, Zhang Y.: Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats. Toxicol Appl Pharmacol. 2014;280(1):169-76.

(309)　Zhai X, Chen X, Ohta S, Sun X.: Review and prospect of the biomedical effects of hydrogen. Med Gas Res.2014;4(1):19.

(310)　Liu L, Xie K, Chen H, Dong X, Li Y, Yu Y, Wang G, Yu Y.: Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis. Brain Res. 2014;1589:78-92.

(311)　Shen M., Zhang H, Yu C, Fan Wang F, SunX.:A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine. Med Gas Res. 2014; 4:17.

(312)　Cui Y, Zhang H, Ji M, Jia M, Chen H, Yang J, Duan M.: Hydrogen-rich saline attenuates neuronal ischemia – Reperfusion injury by protecting mitochondrial function in rats. J Surg Res. 2014;192(2):564-72.

(313)　Xie K, Liu L, Yu Y, Wang G.: Hydrogen gas presents a promising therapeutic strategy for sepsis. Biomed Res Int. 2014;2014:807635.

(314)　Kato R, Nomura A, Sakamoto A, Yasuda Y, Amatani K, Nagai S, Sen Y, Ijiri Y, Okada Y, Yamaguchi T, Izumi Y, Yoshiyama M, Tanaka K, Hayashi T.: Hydrogen gas attenuates embryonic gene expression and prevents left ventricular remodeling induced by intermittent hypoxia in cardiomyopathic hamsters. Am J Physiol Heart Circ Physiol. 2014;307(11):H1626-33.

(315)　Kurioka T, Matsunobu T, Satoh Y, Niwa K, Shiotani A.: Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species. Neurosci Res. 2014;89:69-74.

(316)　Drabek T, Kochanek PM.: Improving outcomes from resuscitation from hypertension and hemodilution to therapeutic hypothermia to H2.Circulation. 2014;130(24):2133-5.

(317)　Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Ohta S, Fukuda K, Hori S.: Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management . Circulation. 2014;130(24):2173-80.

(318)　Yoon YS, Sajo ME, Ignacio RM, Kim SK, Kim CS, Lee KJ.: Positive effects of hydrogen water on 2, 4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice. Biol Pharm Bull.2014 ;37(9):1480-5.

(319)　Ren JD, Ma J, Hou J, Xiao WJ, Jin WH, Wu J, Fan KH.: Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice. Mediators Inflamm. 2014;2014:930894.

(320)　Liu L, Xie K, Chen H, Dong X, Wang G, Yu Y.: Role of Nrf2 in the protective effects of hydrogen against cerebral dysfunction in septic mice. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014;26(9):629-33.

(321)　Homma K, Yoshida T, Yamashita M, Hayashida K, Hayashi M, Hori S.: Inhalation of hydrogen gas is beneficial for preventing contrast-induced acute kidney injury in rats. Nephron Exp Nephrol. 2014;128:116-22.

(322)　Ohta S.: Molecular hydrogen as a novel antioxidant: Overview of the advantages of hydrogen for medical applications. Methods Enzymol. 2015;555:289-317.

(323)　Nakata K, Yamashita N, Noda Y, Ohsawa I.: Stimulation of human damaged sperm motility with hydrogen molecule. Med Gas Res. 2015;5(1):2.

(324)　Du Z, Jia H, Liu J, Zhao X, Xu W.: Effects of three hydrogen-rich liquids on hemorrhagic shock in rats. J Surg Res. 2015;193(1):377-82.

(325)　Zhang JY, Song SD, Pang Q, Zhang RY, Wan Y, Yuan DW, Wu QF, Liu C.: Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice.. World J Gastroenterol. 2015;21(14):4195-209.

(326)　Huang T, Wang W, Tu C, Yang Z, Bramwell D, Sun X.: Hydrogen-rich saline attenuates ischemia-reperfusion injury in skeletal muscle. J Surg Res. 2015;194(2):471-80.

(327)　Luo ZL, Cheng L, Ren JD, Fang C, Xiang K, Xu HT, Tang LJ, Wang T, Tian FZ.: Hydrogen-rich saline protects against ischemia/reperfusion injury in grafts after pancreas transplantations by reducing oxidative stress in rats. Mediators Inflamm. 2015;2015:281985.

(328)　Wang X, Yu P, YongYang, Liu X, Jiang J, Liu D, Xue G.: Hydrogen-rich saline resuscitation alleviates inflammation induced by severe burn with delayed resuscitation. Burns. 2015;41(2):379-85.

(329)　Shi Q, Liao KS, Zhao KL, Wang WX, Zuo T, Deng WH, Chen C, Yu J, Guo WY, He XB, Abliz A, Wang P, Zhao L.: Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF- B pathway. Mediators Inflamm. 2015;2015:685043.

(330)　Yuan L, Chen X, Qian L, Shen J, Cai J.: Administration of hydrogen-rich saline in mice with allogeneic hematopoietic stem-cell transplantation. Med Sci Monit. 2015;21:749-54.

(331)　McCarty MF.: Potential ghrelin-mediated benefits and risks of hydrogen water. Med Hypotheses. 2015;84(4):350-5.

(332)　Ostojic SM.: Molecular hydrogen in sports medicine: New therapeutic perspectives. Int J Sports Med. 2015;36(4):273-9.

(333)　Zhai Y, Zhou X, Dai Q, Fan Y, Huang X: Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats. Exp Mol Pathol. 2015;98(2):268-276.

(334)　Wu Q, Su N, Cai J, Shen Z, Cui J.: Hydrogen-rich water enhances cadmium tolerance in Chinese cabbage by reducing cadmium uptake and increasing antioxidant capacities. J Plant Physiol. 2015;175:174-82.

(335)　太田成男：水素医学の創始，展開，今後の可能性：広範な疾患に対する分子状水素の予防ならびに治療の臨床応用へ向かって　生化学2015;87(1)82-90.

(336)　太田成男：医療への水素利用　ケミカルエンジニアリング　2015 ;60(3) :42(206)-48(212).

(337)　Ostojic SM, Stojanovic MD.: Hydrogen-rich water affected blood alkalinity in physically active men. Res Sports Med. 2014;22(1):49-60.

(338)　Ostojic SM.: Targeting molecular hydrogen to mitochondria: Barriers and gateways. Pharmacol Res. 2015 ;94:51-3.

(339)　Lee PC, Yang YY, Huang CS, Hsieh SL, Lee KC, Hsieh YC, Lee TY, Lin HC.: Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen-rich saline and N-acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats. Hepatol Res. 2015;45(5):578-88.

(340)　Liu H, Liang X, Wang D, Zhang H, Liu L, Chen H, Li Y, Duan Q, Xie K.: Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury. Shock. 2015;43(5):504-11.

(341)　Guo SX, Jin YY, Fang Q, You CG, Wang XG, Hu XL, Han CM.: Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats. PLoS One. 2015;10(4):e0124897.

(342)　Takeuchi S, Nagatani K, Otani N, Nawashiro H, Sugawara T, Wada K, Mori K.: Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats. BMC Neurosci. 2015;16(1):22.

(343)　Song G, Lin Q, Zhao H, Liu M, Ye F, Sun Y, Yu Y, Guo S, Jiao P, Wu Y, Ding G, Xiao Q, Qin S.: Hydrogen activates ATP-binding cassette transporter A1-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia: a double-blinded, randomized and placebo-controlled trial. J Clin Endocrinol Metab. 2015: 100(7):2724-33.

(344)　Yokota T, Kamimura N, Igarashi T, Takahashi H, Ohta S, Oharazawa H.: Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina. Clin Experiment Ophthalmol. 2015;43(6):568-77.

(345)　Pshenichnyuk SA, Komolov AS.: Dissociative electron attachment to resveratrol as a likely pathway for generation of the H2 antioxidant species inside mitochondria. J Physical Chem Lett 2015;6(7):1104-10.

(346)　Liu F, Liu YB, Li, JS, Huang H.: Liu F, The role of hydrogen in plant stress tolerance. Zhiwu Shengli Xuebao/Plant Physiology Journal 2015; 51 (2):141-52. （中国語）

(347)　hang CB, Tang YC, Xu XJ, Guo SX, Wang HZ.: Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-κB signaling pathway. Experimental and Therapeutic Med. 2015;9 (6):2114-20.

（上へ）

(348)　Zhang Y, Liu Y, Zhang J.: Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction. J Surg Res. 2015;198(1):41-9.

(349)　Wei R, Zhang R, Xie Y, Shen L, Chen F.: Hydrogen suppresses hypoxia/reoxygenation-induced cell death in hippocampal neurons through reducing oxidative stress. Cell Physiol Biochem. 2015;36(2):585-98.

(350)　Peng Z, Chen W, Wang L, Ye Z, Gao S, Sun X, Guo Z.: Inhalation of hydrogen gas ameliorates glyoxylate-induced calcium oxalate deposition and renal oxidative stress in mice. Int J Clin Exp Pathol. 2015;8(3):2680-9.

(351)　Chen X, Liu Q, Wang D, Feng S, Zhao Y, Shi Y, Liu Q.: Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury. Oxid Med Cell Longev. 2015;2015:106836.

(352)　Jing L, Wang Y, Zhao XM, Zhao B, Han JJ, Qin SC, Sun XJ.: Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats. Heart Lung Circ. 2015;24(6):602-10.

(353)　Zhang H, Yu Y, Ma X, Yang T, Hu N, Wang G.: Effects of hydrogen inhalation on serum pro-inflammatory factors and intestinal injury in mice with severe sepsis. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015;27(6):498-503. （中国語）

(354)　Chen S, Jiang W.: Effect of hydrogen injected subcutaneously on testicular tissues of rats exposed to cigarette smoke. Int J Clin Exp Med. 2015;8(4):5565-70.

(355)　Tange Y, Takesawa S, Yoshitake S.: Dialysate with high dissolved hydrogen facilitates dissociation of indoxyl sulfate from albumin. Nephrourol Mon. 2015;7(2):e26847.

(356)　Guan Z, Li HF, Guo LL, Yang X.: Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells. Arch Gynecol Obstet. 2015;292(2):337-42.

(357)　Zhang, X., Zhao, X., Wang, Z., Shen, W., Xu, X.: Protective effects of hydrogen-rich water on the photosynthetic apparatus of maize seedlings (Zea mays L.) as a result of an increase in antioxidant enzyme activities under high light stress. Source of the DocumentPlant Growth Regulation2015;77(1):43-56.

(358)　Tamasawa A, Mochizuki K, Hariya N, Saito M, Ishida H, Doguchi S, Yanagiya S, Osonoi T.: Hydrogen gas production is associated with reduced interleukin-1β mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients. Eur J Pharmacol. 2015;762:96-101.

(359)　Du Z, Liu J, Jia H, Xu W, Zhao X.: Three hydrogen-rich solutions protect against intestinal injury in uncontrolled hemorrhagic shock. Int J Clin Exp Med.2015;8(5):7620-6.

(360)　Guo SX, Fang Q, You CG, Jin YY, Wang XG, Hu XL, Han CM.: Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation. J Transl Med. 2015 ;13:183.

(361)　太田成男：分子状水素医学：広範な疾患治療と予防医学の応用へ向かって　臨床麻酔　2015-6;39(6)832-39.

(362)　Yu Y, Wang WN, Han HZ, Xie KL, Wang GL, Yu YH.: Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin. Genet Mol Res. 2015 ;14(2):6202-12.

(363)　Chen H, Xie K, Han H, Li Y, Liu L, Yang T, Yu Y.: Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway . Int Immunopharmacol. 2015;28(1):643-54.

(364)　Song G, Zong C, Zhang Z, Yu Y, Yao S, Jiao P, Tian H, Zhai L, Zhao H, Tian S, Zhang X, Wu Y, Sun X, Qin S.: Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice. Free Radic Biol Med.2015;87:58-68.

(365)　Ma XD, Song JN, Zhao YL, Zhang BF, Li DD, Liu ZW, Zhao JJ, Zhao YH.: Changes of immuno-inflammatory responses by intraperitoneal injection of hydrogen after diffuse axonal injury in rats. Journal of Xi’an Jiaotong Univ. (Med. Sci.)2015;36(1):23-7 and 33.

(366)　Lv CY, Zhang Y, He SM, Yu MX.: Application and research progress of hydrogen in metabolic diseases. Fudan University Journal of Medical Sciences 2014;41(5):701-5.

(367)　Qi L, Zhang L, Zhang Z.: Hydrogen research in ophthalmology 2014 Zhonghua Shiyan Yanke Zazhi/Chinese Journal of Experimental Ophthalmology. 2014;32(11):1052-6.

(368)　Shin W.: Medical applications of breath hydrogen measurements Chemosensors and Chemoreception. Analytical and Bioanalytical Chemistry 2014;406(16)3931-9.

(369)　Zeng K, Huang H, Jiang XQ, Chen XJ, Huang W.: Protective effects of hydrogen on renal ischemia/reperfusion injury in rats Sichuan Da Xue Xue Bao Yi Xue Ban. 2014;45(1):39-42.

(370)　You YX, Li JJ, Li YJ, Ma K.: Neuroprotective effects of saturated hydrogen water on retinal ganglion cells in rat optic nerve crush model. Ophthalmology in China 2014;23(2):107-10.

(371)　Xie Q, Li XX, Zhang P, Li JC, Cheng Y, Feng YL, Huang BS, Zhuo YF, Xu GH.: Hydrogen gas protects against serum and glucose deprivation-induced myocardial injury in H9c2 cells through activation of the NF-E2-related factor 2/heme oxygenase 1 signaling pathway. Mol Med Rep. 2014;10(2):1143-9.

(372)　Mei K, Zhao S, Qian L, Li B, Ni J, Cai J.: Hydrogen protects rats from dermatitis caused by local radiation. J Dermatolog Treat. 2014;25(2):182-8.

(373)　Hu H, Li P, Wang Y, Gu R.: Hydrogen-rich water delays postharvest ripening and senescence of kiwifruit. Food Chem. 2014;156:100-9.

(374)　Cui W, Fang P, Zhu K, Mao Y, Gao C, Xie Y, Wang J, Shen W.: Hydrogen-rich water confers plant tolerance to mercury toxicity in alfalfa seedlings. Ecotoxicol Environ Saf. 2014;105:103-11.

(375)　Lin Y, Zhang W, Qi F, Cui W, Xie Y, Shen W.: Hydrogen-rich water regulates cucumber adventitious root development in a heme oxygenase-1/carbon monoxide-dependent manner. J Plant Physiol. 2014;171(2):1-8.

(376)　Chen M, Cui W, Zhu K, Xie Y, Zhang C, Shen W.: Hydrogen-rich water alleviates aluminum-induced inhibition of root elongation in alfalfa via decreasing nitric oxide production. J Hazard Mater. 2014;267:40-7.

(377)　Shimouchi A, Nose K, Mizukami T, Che DC, Shirai M.: Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas. Adv Exp Med Biol. 2013;789:315-21.

(378)　Sutherland BA, Harrison JC, Nair SM, Sammut IA.: Inhalation gases or gaseous mediators as neuroprotectants for cerebral ischaemia. Curr Drug Targets. 2013;14(1):56-73.

(379)　 Zhou L, Wang X, Xue W, Xie K, Huang Y, Chen H, Gong G, Zeng Y.: Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits. Brain Res. 2013;1517:150-60.

(380)　Xia, C., Liu, W., Zeng, D., Zhu, L., Sun, X., Sun, X.: Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B. Clinical and Translational Sci. 2013; 6(5:372-375

(381)　Li GM, Tian M, Ji MH, Zeng QT, Yuan D, Si YN, Sun XJ,Bao HG, Yang JJ.: Protective effects of hydrogen-rich saline on acute kidney injury in rats with sepsis. Chinese J Emergency Med. 2013;22 (5):472-5.

(382)　Han HZ, Xie KL, Chen HG, Shi Y, Wang T, Yu YH.: The protective effects of hydrogen inhalation on renal injury in severe septic mice. Chinese Journal of Emergency Medicine 2013;22 (3):255-9.

(383)　Jiang H, Yu P, Qian DH, Qin ZX, Sun XJ, Yu J, Huang L.: Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ratio and inhibits advanced glycation end product-induced apoptosis. Int J Mol Med. 2013;31(6):1381-7.

(384)　Wang, J.-G., Lin, J.-Y., Kong, D.-Q., Zhang, Z.-L., Yu, X.-M., Liu, J.-Q., Cai, D.-M.: Hydrogen can alleviate post-cardiac arrest brain injury in rabbits. Chinese J Emergency Med. 2012; 21 (10):1111-1115.

(385)　Ge P, Zhao J, Li S, Ding Y, Yang F, Luo Y.: Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress. Neurol Res. 2012;34(2):187-94.

(386)　Shimouchi A, Nose K, Shirai M, Kondo T.: Estimation of molecular hydrogen consumption in the human whole body after the ingestion of hydrogen-rich water. Adv Exp Med Biol. 2012;737:245-50.

(387)　Dong WB, Zheng GL.: Progress in hydrogen medicine. Chinese Journal of Pharmacology and Toxicology. 2012; 26 (5) 669-673.

(388)　Wang, J.-G., Lin, J.-Y., Kong, D.-Q., Zhang, Z.-L., Yu, X.-M., Liu, J.-Q., Cai, D.-M.: Hydrogen can alleviate post-cardiac arrest brain injury in rabbits. Chinese J Emergency Med. 2012; 21 (10):1111-1115.

(389)　Qi, HH, Song J, Chen YX.: Protective effect of hydrogenrich saline on alcohol-induced liver injury in rats. World Chinese J.Digestol. 2012;20 (15)1328-32.

(390)　Cui YM, Cheng HX, Zeng XM, Zeng QT, Gao W, Duan ML, Xu JG.: Effects of hydrogen-rich saline on hippocampus mitochondrial permeability transition pore and apoptosis of rats with global cerebral ischemia-reperfusion injury. Chinese Pharmacological Bulletin 2012;28(6):853-8

(391)　Carbonero F, Benefiel AC, Gaskins HR. : Contributions of the microbial hydrogen economy to colonic homeostasis. Nat Rev Gastroenterol Hepatol. 2012;9(9):504-18.

(392)　Chuai Y, Qian L, Sun X, Cai J.：Molecular hydrogen and radiation protection.　Free Radic Res. 2012;46(9):1061-7.

(393)　Xiao X, Cai J, Xu J, Wang R, Cai J, Liu Y, Xu W, Sun X, Li R.: Protective effects of hydrogen saline on diabetic retinopathy in a streptozotocin-induced diabetic rat model. J Ocul Pharmacol Ther. 2012;28(1):76-82.

(394)　Chen HG, Xie KL, Han HZ, Yu YH.: The mechanisms for the lung tissue protective effects of hydregen : recent progress in mice study. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011;23(11):696-8.

(395)　Zhang, H.-L., Liu, Y.-F., Luo, X.-R., Tan, W.-H., Chen, G.-J.: Effects of hydrogen saturated saline on the lung after paraquat poisoning. Chinese Journal of Emergency Medicine 2011;20 (7) : 708-11.

(396)　Qiu XC, Jin YC, Sun Y, Luo PF, Fu JF, Chen B, Xia ZF.: Effect of hydrogen-rich saline on blood pressure and antioxidant ability of lung tissue in scalded rats following delayed resuscitation. Zhonghua Shao Shang Za Zhi. 2010;26(6):435-8.

(397)　Chen QB et al. Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress and BDNF in spinal cord in a chronic constriction injury rat model. Brain res. 2010.

(398)　Huang et al. Hydrogen Gas Inhalation Attenuates Ventilator-Induced Lung Injury In Mice. Am J Respir Crit Care Med. 2010; 181: A3751.

（上へ）